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Retatrutide Dosing Protocol Standard Dosing Schedule Starting dose : 0.25 mg once weekly Week 4 : Increase to 0.5 mg if tolerated Week 8 : Increase to 1 mg Week 12 : Increase to 1.5 mg (maintenance for many) Week 16+ : Optional increase to 2 mg (max recommended) Optimal Protocol for Body Recomposition For those prioritizing muscle gain + fat loss (recomp): Start at 0.5 mg weekly (skip 0.25 week if experienced) Increase by 0.5 mg every 2-3 weeks until appetite suppression is noticeable Find your sweet spot (typically 1-1.5 mg) where hunger is controlled but energy is high Maintain at that dose indefinitely The key is finding the minimum effective dose, not always maxing out

Both medications have shown significant results for controlling blood sugar levels in people with type 2 diabetes and weight loss for people with obesity or overweight

Peptide Vials (Semaglutide, 10 mg each): 8 weeks 1 vial (3 mg total used) 12 weeks 1 vial (7 mg total used) 16 weeks 2 vials (13.8 mg total used) 20 weeks 3 vials (23.4 mg total used with maintenance dosing) Insulin Syringes (U-100): Per week: 1 syringe 8 weeks: 8 syringes 12 weeks: 12 syringes 16 weeks: 16 syringes 20 weeks: 20 syringes Bacteriostatic Water (10 mL bottles): Use ~3.0 mL per vial for reconstitution

Methodologies, limitations, and citations are also available in the full report

These medications help regulate blood sugar and appetite levels by increasing insulin production and decreasing glucose production in the liver