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It is engineered with two structural modifications relative to the 70-residue native protein: a substitution of arginine for glutamic acid at the third position and a 13-amino-acid extension at the N-terminus, giving a total length of 83 amino acids
But the greatest reduction in skin health is observed when women turn 50 years and experience menopause, which has a dramatic negative impact on skin aging owing to the loss of estrogen production from the ovaries, specifically the most potent estrogen in the body, which is 17-estradiol [2, 10, 14, 15]
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It occurs under basal non-stress conditions but has mostly been documented in response to oxidative stress conditions (Zaffagnini et al., 2012)
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