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Ishihara T, Yoshida M, Arita M
Common contributors include sleep disorders, chronic stress, hormonal imbalances (particularly thyroid dysfunction), nutritional deficiencies (such as vitamin B12 or iron), autoimmune conditions (like multiple sclerosis or lupus), medications, and metabolic disorders including diabetes
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These incretin-based medications work by mimicking naturally occurring hormones that enhance insulin secretion, suppress glucagon release, slow gastric emptying, and reduce appetite through central nervous system pathways
Periods of exclusivity for pharmaceutical products end as part of their normal life cycle, and generic treatments may become available over time. The company confirmed that protection for semaglutide regulatory submissions in Canada will expire in 2026
