The standard protocol from the SUSTAIN trials (Marso et al., New England Journal of Medicine , 2016): Reduce basal insulin dose by 20% on the day you start semaglutide Monitor fasting blood glucose daily for the first 2 weeks Further reduce basal insulin by 10 to 20% if fasting glucose drops below 80 mg/dL or if hypoglycemia occurs Reduce mealtime (bolus) insulin by 20 to 30% during semaglutide titration, adjusting based on post-meal glucose readings Most patients on basal insulin end up reducing total daily insulin dose by 30 to 50% by the time they reach maintenance semaglutide dose
Technically speaking, it belongs to the glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) families of drugs, but what its important to remember is that most weight loss medications (particularly injectable ones), belong to this family of medications (RedBox)
It is commonly used as a first choice of treatment
7 Managing/evaluating semaglutide risk Potential problems/side effects may be realized as this class of medication is still in its infancy and long-term negative effects may not have been fully realized
Next, we treated the sperm suspensions collected from the cauda epididymis with liraglutide or semaglutide directly