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Neural-Circuit Connectivity While hypothalamic MC4 signaling is well established in appetite-control pathways, downstream projections involving mesolimbic reward regions and autonomic brainstem centers remain incompletely characterized experimentally

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PP metabolites-mediated protection in INS-1 832/3 pancreatic -cells challenged with toxic IAPP aggregates was measured by Lactate Dehydrogenase Test, PI/Annexin V staining and Glucose Stimulated Insulin Secretion (GSIS) assays

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