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MR is strongly recommended as a means of prioritizing drug targets for cardiovascular research, to avoid expensive failures in phase III randomized controlled trials (RCTs) [18, 19] and to identify mechanistic targets of intervention, complementary to RCTs [19]
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Acknowledgements This research was funded by the Swedish Research Council (20142945 to KPS and 20137107 to PR), Novo Nordisk Foundation Excellence project grant (to KPS), Ragnar Sderberg Foundation (to KPS), Harald Jeanssons Stiftelse and Greta Jeanssons Stiftelse (to KPS), Magnus Bergvalls Stiftelse (to KPS), Wallenberg Foundation and Center for Molecular and Translational Medicine (to KPS) and National Institute of Health NIH-DK096139 (to MRH) and NIH-DK104897 (to SEK)
Metformin is taken as an oral tablet, sometimes multiple times a day
Histological efficacy of exenatide was investigated in eight diabetic patients with biopsy-proven NAFLD but, although some improvement in isolated histologic features and fibrosis was demonstrated, there was no statistical significance, most likely due to the small sample size [81]
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