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Comparing the glutathione-scaffold site among a variety of other members of the thioredoxin superfamily also provides an explanation for their disulfide substrate preferences, for example, why glutaredoxins prefer GSSR in contrast to thioredoxins lacking most of the relevant residues (Fig

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In in vivo models, researchers evaluate the influence of this cascade on the subsequent release of IGF-1 (Insulin-like Growth Factor-1) in the liver

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