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Compounded GLP-1 medications are custom-made formulations available when the brand-name medication is in short supply or when the patient needs a custom dose or formulation that is not commercially available
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This lack of effect on stress hormones was evident even at doses more than 200-fold higher than the ED50 for growth hormone release, establishing ipamorelin as the first GHRP-receptor agonist with selectivity for growth hormone release similar to GHRH itself
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According to the researchers, their findings broadly suggest that small-molecule GLP-1s could have applications in dysregulating reward signaling, creating implications for the drugs treatment of substance-use disorder and binge-eating
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