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Similarly, mice lacking the anti-inflammatory cytokine interleukin 10 (IL-10 -/- mice) spontaneously develop colitis after weaning whereby onset and severity of inflammation are dependent on the microbiota and the genetic background of mice (40), with the 129/SvEv mouse line being more susceptible than C57BL/6 mice
366 Reticulophagy is a receptor-mediated form of selective autophagy that promotes cell survival, tumor progression, and chemoresistance across multiple cancers by maintaining endoplasmic reticulum homeostasis and buffering therapy-induced stress
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Moreover, the top-ranked peptide did not contain the amino acids in its sequence considered important for activating the GLP-1R and was thus reserved for future evaluations
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