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Under the Federal Food, Drug, and Cosmetic Act, failure to follow these rules renders drug products adulterated ( [15] )
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If a material is offered for research use only, the buyer cannot treat product availability as evidence of therapeutic legitimacy
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By 2016, a review of tamoxifen trials in bipolar disorder concluded that tamoxifen was effective in the short-term treatment of mania, with results similar to lithium or valproate, with about 50% response rate across all three drugs
