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5.4 GIP and GLP-1 effects on lipid and glucose metabolism in adipose tissue and liver Fat and liver are two organs that play key roles in lipid and glucose metabolism, working together in concert and complimentarily to maintain lipid and glucose homeostasis
Specifically, the strongest comparison was with insulin (hazard ratio [HR], 0.68 [95% CI, 0.63 to 0.74]) while the weakest significant comparison was with other GLP-1RAs (HR, 0.88 [CI, 0.81 to 0.96])
This peptide-pathway genetic assessment maps 14 metabolic pathways and 49 peptide variants, including key GLP-1 receptor genes (GLP1R rs6923761) and weight-regulation pathways (FTO rs9939609, MC4R rs17782313)
Timing Baseline Marker Fasting glucose Why it matters Gives a current glucose snapshot, especially when appetite and medication needs change
Salah K, Stienen S, Pinto YM et al (2019) Prognosis and NT-proBNP in heart failure patients with preserved versus reduced ejection fraction
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