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Lilly's 2026 story still runs through tirzepatide
Options include: Metoclopramide : May help with delayed gastric emptying but should only be used for short courses (maximum 5 days) due to risk of neurological side effects Prochlorperazine : Can be effective for nausea and vomiting Cyclizine : An alternative that works through a different mechanism Ondansetron : Sometimes used but may cause constipation Domperidone : Used cautiously due to risk of heart rhythm problems (QT prolongation), particularly in older adults, those with heart conditions, or those taking other medications affecting heart rhythm For people with diabetes, it's important to follow sick-day rules if experiencing vomiting
(PubMed) Bhagavan HN, Chopra RK
So, in effect, the GLP-1s replace a hormone that gets low when people try to lose weight, thus allowing for sustained weight loss without the person feeling hungry all the time
Wegovy has been shown in the SELECT trial to reduce the risk of major cardiovascular events in people with overweight or obesity and existing heart disease
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