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semaglutide 1 mg, n=1,879): The pivotal head-to-head trial demonstrated superiority of tirzepatide at all doses over semaglutide 1 mg for HbA1c reduction (-2.01%, -2.24%, -2.30% vs
Abbreviations and Acronyms ARNI = angiotensin receptor-neprilysin inhibition CMR = cardiac magnetic resonance CRT = cardiac resynchronization therapy HFimpEF = heart failure with improved ejection fraction HFmrEF = heart failure with mildly reduced ejection fraction HFpEF = heart failure with preserved ejection fraction HFrEF = heart failure with reduced ejection fraction ICD = implantable cardioverter-defibrillator LVAD = left ventricular assist device NICM = nonischemic cardiomyopathy SGLT2i = sodium glucose co-transporter 2 inhibitor SMR = secondary mitral regurgitation Funding Support and Author Disclosures Dr DeFilippis serves on a clinical trial committee for Abiomed and has had speaker engagements with AstraZeneca
Understanding the distinction between medication-related adverse effects and pre-existing risk factors is crucial for informed decision-making
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