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Despite this, the salient role of overall vagal signaling in energy homeostasis has been established, as surgical or chemical ablation of vagal afferent signaling decreases acute sensitivity to intestinal nutrients, leading to increased food intake and reduced NTS neural activation 23,24,42,43,44

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Semaglutide may cause mild dehydration through its appetite-suppressing effects, and creatine requires adequate hydration to work safely and avoid kidney strain

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