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For B/C: Gray bars indicate GSH/GSSG-Glo Assay only, whereas green bars indicate GSH/GSSG-Glo Assay multiplexed with the CellTox Green Cytotoxicity Assay

One of the latest systematic reviews on the topic covered a total of 4 trials and reported significant improvement in the condition, assessed according to a 72-point scale called Psoriasis Area and Severity Index (PASI)

Mechanistically, these effects are linked to GLP-1 RA-mediated suppression of inflammatory pathways, modulation of skeletal muscle metabolism, and preservation of mitochondrial function, thereby influencing insulin resistance

The liver's cytochrome P450 enzyme system, particularly CYP3A4, plays a significant role in breaking down these compounds

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