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The pharmacokinetics of tirzepatide after a single 5 mg dose were evaluated in patients with different degrees of hepatic impairment (mild, moderate, severe) compared with subjects with normal hepatic function [see Use in Specific Populations (8.7)]
The cationic core corresponds to the free-base formula C10H11N2+ with a formula weight of 215.26 g/mol and CAS 1034043-18-3
They cluster during escalation and usually ease at a held dose
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