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An uncommon Mounjaro side effect that may affect up to 1 in 100 people is injection site pain
Using a model of streptozotocin diabetes in rats in vivo and HT-22 cells in vitro, it was shown that GLP-1RA liraglutide improves the cognitive abilities of rats with diabetes mellitus and can have a protective effect by reducing oxidative stress, suppressing the expression of -secretase (BACE1) and -secretase, as well as reducing the deposition of -amyloid by triggering signaling mechanisms associated with NF-kB and ERK1/2 [30]
Glucagon-like peptide-1 (GLP-1): It is responsible for slowing down the digestion process and is associated with decreased food intake in animal models
References include the SURMOUNT-1 trial publication (Jastreboff et al., New England Journal of Medicine , 2022), the FDA Adverse Event Reporting System dataset accessed Q1 2026, and the National Institutes of Health (NIH) clinical guidance on night sweats and medication-induced hyperhidrosis
Their mechanisms of action, dosing forms, and required dosage differ, and they have varying efficacy in controlling blood sugar levels and promoting weight loss
