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Menstrual changes during treatment reflect temporary shifts in hormone signaling caused by weight loss, not damage to reproductive tissue
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Here is what went into this page specifically: I pulled the full text of the SURMOUNT-5 head-to-head trial published in the New England Journal of Medicine on May 11, 2025 (DOI: 10.1056/NEJMoa2416394) and cross-referenced it with the Phase 3 TRIUMPH-4 topline readout from Eli Lilly on December 11, 2025
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