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Discussing this with biotech/pharma sponsors and building some dose escalation buffer into a protocol to keep the participant in the study and manage these AEs (when possible) can be a good strategy to keep participants in the trial & improve their experience
While choline and methionine are intended to support liver health, a severely compromised liver may not process these substances effectively
10.1016/j.neulet.2013.12.019 135 ZhaoM.ChenJ
Optimal Testing Schedule Your unique health history and medication response determine your ideal monitoring schedule, but these guidelines provide a starting framework: Before Starting Therapy Complete baseline panel including all markers listed above to establish your starting point and identify any pre-existing issues
Absolutely, and you should
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