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GLP-1 receptor agonists led with 38.55% share in 2025
It is a semisolid preparation designed for convenient and controlled application on the skin for localized treatment or absorption of active ingredients
(PubMed) Pons R, De Vivo DC
Regarding the effect of the GLP-1 agonist, since it suppressed the expression of liver lipid synthesis genes FAS and SCD1, and consequently reduced liver triglyceride levels, its effect could be confirmed without measuring protein levels
Additionally, the mucosal layer represents a major yet often overlooked barrier, acting as a dense, heterogenous matrix that traps and limits the diffusion of hydrophobic or charged peptides ( in vitro models, the limitations of which are not fully realized in the current formulation design space ( At the epithelial surface, paracellular transport is restrained by tight junctions, whereas transcellular uptake is constrained by efflux transporters and competition with endogenous substrates (Hamman et al., 2005)
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