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Detection Method: Colormetric
The Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF-JAK) /STAT5- CCAAT/enhancer-binding protein (C/EBP) pathway can activate Acod1 to produce itaconate, mediating Nuclear factor erythroid 2related factor 2 (Nrf2)-dependent ferroptosis resistance and maintaining TIN persistence [48]
A qualifying plan must set enrollment goals disaggregated by race, ethnicity, sex, and age group for the clinically relevant study population ( [5] ), and sponsors must justify those goals, particularly where they diverge from the estimated prevalence or incidence of the disease in question ( [26] )
2023 Jul;78:127188
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