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Lysosomal lipid hydrolysis provides substrates for lipid mediator synthesis in murine macrophages
For example: Endogenous GHRH has a half-life of ~515 minutes Native GLP-1 is broken down in under 2 minutes Thats why natural peptides are rarely used directly in therapeutics theyre too unstable
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Control mice were treated with 0.85% saline in water
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