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Contraindications and Safety Considerations That Affect Switching Decisions Before initiating tirzepatide or any incretin agent, screen for a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

PMID: 41838190 Cell Rep 2025 Apr 16;44(5):115572

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Based on Phase 2 clinical trials, patients with T2DM who were inadequately managed with diet and exercise alone or were on a stable metformin regimen for at least 3 months before screening received once-weekly subcutaneous injections of tirzepatide at doses of 1 mg, 5 mg, 10 mg, or 15 mg for 26 weeks

The following guidance outlines practical strategies to help reduce symptoms and improve tolerance of treatment