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The new vials priced at $399 and $549, respectively, for a month's supply are a lower-cost alternative to the current injector pen formulation of Zepbound and are easier to produce

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1 to 2% after oral administration of 1.5 mg, 4 mg and 9 mg of RYBELSUS (formulation R2)

The method of any one of claims 719-728, wherein the trans-epithelial administration provides a maximum plasma concentration (Cmax) of the glucagon receptor agonist or GLP-1 receptor agonist in systemic circulation ((Cmax)TE) that is at least about 10%, at least about 15%, at least about 20%, at least about 25%, or at least about 30% of the C max in systemic circulation provided by subcutaneous administration of the same amount of the glucagon receptor agonist or GLP-1 receptor agonist ((C max ) SC ), respectively