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One very small human study did report that some participants with knee pain felt relief, but this is far from the large-scale, controlled evidence needed to prove it works

The mean reduction in body weight at 48 weeks was 24.2% in the 12-mg group the largest reduction observed to date in a Phase 2 trial of an anti-obesity medication. Jastreboff et al., New England Journal of Medicine, 2023 Beyond weight loss, retatrutide produced a result that surprised researchers: dramatic reductions in liver fat

These are complementary mechanisms, though combination effects have not been studied

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Developmental pharmacology, drug disposition, action, and therapy in infants and children