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An efficacious oral GLP-1 therapy would be an important advance for diabetes and obesity treatment

They often mean more side effects without additional metabolic benefit

Tirzepatide (Mounjaro) has produced some of the largest weight-loss results seen with this class in obesity trials [9], though GI side effects can be strong early on

While the exact mechanisms are still being explored, researchers believe GLP-1s may impact the brains reward pathways, which could have implications for alcohol use disorder

Protocols for fluorescence exposure of slices were controlled by software (Live Acquisition, TillVision), and analyses were conducted using Offline Analysis (TillVision)