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Rather than pharmacologically activating one receptor with sustained supraphysiological stimulation, as you do with a semaglutide, Amarasate activates bitter taste receptors present throughout the gastrointestinal tract. Earlier work by the same group showed the extract raises blood levels of three satiety hormones, chemical messengers the digestive tract releases to signal fullness
It is also thought to contribute to a number of health issues including cardiovascular diseases, Alzheimers, Parkinsons and diabetes
Furthermore, platelet activation leads to more inflammatory signaling, which contributes to the progression of kidney damage