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This multi-level regulation keeps glutamate within its tight physiologic range. Excess causes excitotoxic neuronal death (as in stroke), while deficiency impairs learning and memory

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J Agric Food Chem

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The comparatively high values for Vss of free cobalamins-(III) are due to the high protein binding of hydroxocobalamin as it reacts in the blood with plasma constituents to form cobalamins-(III) complexes and the rapid distribution of free cobalamins-(III) into tissues

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