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Bao et al., 1997), and directly reduces membrane-bound phospholipid hydroperoxides in situ and thus protects against membrane damage

Genetic variants affecting GIP or GLP-1 receptor function might identify patients most likely to benefit from dual agonism

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A Phase I trial of the small non-peptide GLP-1 receptor agonist danuglipron in 98 patients with type 2 diabetes found that it had a similar glucose-lowering ability as the clinically used GLP-1 receptor agonists and was well tolerated during the 4 week study period [43]