The AUC was reduced in the GLP-1RA group as compared to the control group ((F(1,14) = 3.98 p = 0.06, f = 0.55)
Upon ingestion of glucose and nutrients, incretin hormones (GIP and GLP-1) are secreted by endocrine cells that are in the epithelium of the small intestine and stimulate insulin secretion from pancreatic cells
Exposure to high temperatures (above the recommended limits) can cause the protein structure to denature or break down, reducing the medication's potency
Slower Titration for High-Risk Patients Patients over 70 years, patients with a baseline eGFR below 45 mL/min/1.73 m, and patients with pre-existing upper GI motility disorders (gastroparesis, functional dyspepsia) should follow an extended schedule that doubles each dose interval to 8 weeks rather than 4
Dose escalations are happening, weight loss is accelerating, fluid intake hasn't yet adapted