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In the context of the full-length enzyme elucidated here, the SAM-mediated conformational change creates a central filament stalk composed of repeating units of the SAM-bound RD dimer, arranged in an antiparallel daisy-chain like fashion due to the interactions of the loop 516525 with the neighbouring subunit (Fig
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The optimal dosing, administration route, and cycling protocol for humans remain uncertain
Its ability to simultaneously address multiple metabolic dysfunctions makes it a promising therapeutic agent for the management of obesity and metabolic disease
Proctor et al., 2008), indicating reliance on specific transporter proteins for its uptake
