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PLoS ONE 8 , e71108

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ADA 2026: TRANSCEND-T2D-1: Retatrutide Demonstrates Robust Reductions in HbA1c and Body Weight as Monotherapy in Type 2 Diabetes The phase 3 TRANSCEND-T2D-1 trial evaluated the triple GIP, GLP-1, and glucagon receptor agonist in adults with type 2 diabetes inadequately controlled with diet and exercise alone

It is contraindicated in pregnancy and breastfeeding, can cause significant irritation, and increases photosensitivity