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Another study found that GLP-1R activation in Brunners glands upregulated barrier defense genes, an effect entirely absent in GLP-1R knockout mice ( GLP-1 also modulates local inflammation through specialized cell populations
This finding implies that the enhanced release of GSH into the extracellular space may play a role in the upregulation of GPX3 activity within the TME
Emerging insights into HAUSP (USP7) in physiology, cancer and other diseases
doi: 10.1021/jacs.5c11226 148 HillMVrbkovJZrubovJKanchevaRVelkovMKanchevaLet al
pmid:13655060 9
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