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Smoking and alcohol consumption can also speed up this depletion process

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Vitamin E and Alzheimers disease: what do we know so far?, Clinical interventions in aging (2019)

Research published in the Journal of the International Society of Sports Nutrition found that GPLC supplementation significantly increased plasma nitrate and nitrite levels (markers of nitric oxide production) and reduced post-exercise oxidative stress markers compared to placebo, supporting its inclusion as a carnitine form with dual functionality beyond standard L-Carnitine

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