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These encompass the detonation of sophisticated and improvised nuclear weapons, potential terrorist deployment of radiologic dispersal devices (i.e., dirty bombs), attacks on nuclear power plants, and the occurrence of accidents at these facilities caused by technical failure or natural disasters as happened in Chernobyl, Ukraine in 1986 and Fukushima, Japan in 2011 ( Exposure to ionizing radiation induces the release of damage-associated molecular patterns (DAMPs) by DNA damage and several types of cell death ( Acute radiation syndrome (ARS) The hematopoietic system emerges as the most vulnerable organ to ARS, with discernible symptoms of H-ARS manifesting following exposure to total body irradiation (TBI) exceeding 2 gray (Gy) in humans ( 50/60 , estimating the radiation dose causing lethality in 50% of a population within 60 days, ranges from 3.3-4.5 Gy without medical management to 6-7 Gy with medical intervention, including antimicrobial agents and blood transfusions ( Oxidative stress causes DNA damage by reactive oxygen species (ROS) generated after the ionization of water in the cells
Similar content being viewed by others Introduction Cardiovascularkidneymetabolic (CKM) syndrome encompasses a group of interrelated conditions, including obesity, type 2 diabetes (T2D), cardiovascular disease (CVD), and chronic kidney disease (CKD), significantly contributing to premature morbidity and mortality worldwide [1, 2]
Microbiome 5:79
Insulin sensitizers for improving the endocrine and metabolic profile in overweight women with PCOS
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