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We show that the PfGrx-catalyzed oxidation of roGFP2 occurs via a monothiol mechanism and is up to three orders of magnitude faster when roGFP2 and PfGrx are fused

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This indicates that GHRP-6 works both directly on the pituitary and indirectly through hypothalamic GHRH neurons, and the two pathways function synergistically

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