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ITGA6 is directly regulated by hypoxia-inducible factors and enriches for cancer stem cell activity and invasion in metastatic breast cancer models

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The study utilized human glioblastoma cell lines (U-87, GS-Y01, and GS-Y03) and normal human fibroblasts (IMR-90) to assess cell viability, survivin protein expression, and apoptotic markers through western blotting, cell viability assays, and molecular biology techniques

Naltrexone is an opioid antagonist originally developed for alcohol and opioid dependence