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In summary, CCK activates vagal fibres, which in turn activate NST neurons, inducing a feeling of satiety

Interest peaked in this combination after early-phase studies revealed that activating both the GLP-1 system and amylin receptor pathways produced effects that appeared greater than simply adding the individual responsessuggesting true complementary action at the neurological level

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[1] The pharmacokinetic profile of semaglutide contributes to its once-weekly dosing convenience but also has implications for overdose scenarios