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doi: 10.1126/science.1082833 6 AllenJ

Zepbounds official side-effect page says diarrhea, nausea, and vomiting may cause dehydration and advises contacting a healthcare provider right away if nausea, vomiting, or diarrhea does not go away

It can also cause more pain at the injection site because muscle tissue has more nerve endings than fat

22 February 2026

However, chronic inflammation sustains this fibrogenic signaling in the HSC niche, leading to progressive liver fibrosis and ultimately cirrhosis (193196)