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Low-dose naltrexone (LDN) has emerged as one of the most promising agents in this area, working through glial cell modulation to reduce neuroinflammation and through toll-like receptor pathways to quiet abnormal immune activation

10.3389/fphar.2014.00196 5 AstaritaJ

6 Perreault, L., et al., Changes in Glucose Metabolism and Glycemic Status With Once-Weekly Subcutaneous Semaglutide 2.4 mg Among Participants With Prediabetes in the STEP Program

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contraindicated in uncontrolled hypertension Skin : Mild, transient skin hyperpigmentation in some patients (less than MT-2) Cardiovascular : FDA label includes warnings about cardiovascular risk