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Structural optimization revealed that incorporating small hydrophobic groups, such as cyclopropylmethyl, at the N 7 -position enhanced potency, while a sulfonyl group at the N 2 -position and (4-fluorophenyl) amino at the C 3 -position improved metabolic stability (Figures 7A,B)
Simple as that
doi: 10.1016/J.METABOL.2021.154937 14 GiorginoFVoraJFeniciPSoliniA
Cortiana V, Kannan S, Vallabhaneni H, Gambill J, Nadar S, Jigar Kumar Rangrej V, Park CH, Leyfman Y
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