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Early studies with broad-spectrum MMP inhibitors, such as batimastat-94, demonstrated improved barrier integrity and reduced hemorrhagic complications by limiting proteolytic TJ degradation in preclinical models of ischemia and inflammation [259]
When combined with emollients such as hydrogenated polyisobutene, polybutene, caprylic or capric triglyceride and castor seed oil, vitamin C lip gloss helps seal in moisture, soften flaky areas and improve smoothness over time
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