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It is important, to note that variations in biomarker responses within aquatic environments are also often influenced by a range of environmental factors, such as temperature, salinity, diet, and seasonal changes (Hagger et al
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Therefore, it appears that schistosome TGR fulfills all of the major functions of the mammalian TGR, TrxR1, TrxR2, and GR orthologs, emphasizing the importance of the parasite protein, and this alone should make it an attractive target for treatment of schistosomiasis
Their predictive value for gallstone disease is very low since they often occur with functional dyspepsia, gastroesophageal reflux disease, irritable, bowel syndrome, or cardiac disease [96,97,98,99], and can persist after cholecystectomy [13]
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