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Furthermore, the dopamine metabolism process inherent to vulnerable nigrostriatal neurons intrinsically generates ROS, further damaging mitochondrial complex I and proteasome function, creating a vicious cycle of oxidative stress and neurodegeneration [336]
32 RostJ.RapoportS
While the heme may have prooxidant functions in large quantities, heme is constantly turned over and excreted from cells as bilirubin [81]
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