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In our bulk RNAseq data, we noted that pathways such as oxidative phosphorylation and electron transport chain were significantly downregulated ( Supplementary Figures 5B, C )
This SOD1-mediated ERAD impairment induces further ER stress, upregulates zinc transporters and suppresses protein synthesis, positioning SOD1 as a molecular sensor that links zinc status to ER proteostasis failure
It helps to reduce inflammation, thin mucus, and enhance antioxidant protection in the lungs
People can follow a structured daily intake without professional supervision, which makes tablets a more accessible option across Pakistan
Its important to adjust treatment plans for these cases
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