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Strategies for alpha-synuclein reduction have been reviewed recently, and include immunisation (active, passive), reduction of its expression (via small interfering ribonucleic acids and antisense oligonucleotides [ASOs], among other techniques), inhibition of its aggregation, and enhancement of its degradation [96]

Cymbal, Michael et al

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Here, we demonstrate that a peptideantibody conjugate that blocks GIPR while simultaneously activating GLP-1R (GIPR-Ab/GLP-1) requires both CNS GIPR and CNS GLP-1R for maximal weight loss in obese, primarily male, mice

This makes Ipamorelin a promising avenue for those seeking an effective and well-rounded solution to enhance their overall body composition