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Although most macromolecules in the blood are physically prevented from entering the brain due to the presence of the blood-brain barrier and tight junctions, specific and non-specific transcellular mechanisms transport various macromolecules and complexes across the blood-brain barrier
Understanding peptide dosing principles helps frame why gradual escalation exists: it gives your body time to adapt before adding more stimulus
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Hematol J 2000
But certain situations warrant a conversation with your healthcare provider, and waiting too long to have that conversation can allow manageable problems to become entrenched ones
