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C1-27 was able to significantly enhance cisplatin-induced cytotoxicity in a clonogenic assay, at non-cytotoxic concentrations (Fig
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Furthermore, one study has shown that the cyclic peptide DC646 binds to K303 in the ligand-binding domain (LBD) of FXR, triggering conformational changes in the LBD and inhibiting recruitment of the coactivator SRC2 [58]
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