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Mechanistically it adds steric and electrostatic bulk at the same end of the molecule the binding proteins engage, deepening the reduction in affinity beyond what the single substitution achieves alone
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Eligibility Who Is a Good Candidate for GLP-1 Therapy
View Study [2]"A synthetic analog of alpha-melanocyte stimulating hormone that is a superpotent activator of melanogenesis" Sawyer TK, Sanfilippo PJ, Hruby VJ, et al., 1980 Finding: The foundational research that led to MT-2 development showed that synthetic MSH analogs could be far more potent than natural hormones at stimulating melanin production
Most patients tolerate treatment very well
