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Psychiatry 12, 17
2023;81(Suppl 8):1628
14 Why the Difference MattersThe activation of two distinct hormonal pathways (GIP and GLP-1) by tirzepatide, compared to the single pathway (GLP-1) activated by semaglutide, is believed to be the underlying reason for the generally greater effects on weight loss and blood sugar control observed with tirzepatide in clinical studies.32 This dual mechanism provides a plausible scientific basis for why one drug might demonstrate more pronounced results than the other
Novo Nordisk, the Danish drugmaker that manufactures three of the most popular formulations Ozempic, Rybelsus, and Wegovy is conducting a pregnancy registry for Wevogy (the only one of the three approved for use specifically in weight loss), in which it will compare pregnancy outcomes for people exposed to Wegovy during pregnancy, and overweight and obese people who were not exposed during pregnancy
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